Endpoint Adjudication Section
SPIRIT 2025 includes endpoint adjudication committees among the groups that can oversee trial conduct and recommends reporting the relevant group’s role, responsibilities, relationships, and membership. Endpoint adjudication is not required for every trial. Keep this distinct from defining the outcomes themselves: Outcome Measures explains what is measured; adjudication explains how designated endpoint events are reviewed or classified.
An Endpoint Adjudication section explains whether and how study endpoints are independently or centrally reviewed, including the adjudication group’s role and procedures when applicable.
Key details
Important caveats
Scope Boundary
Endpoint adjudication is not required for every trial. Keep this distinct from defining the outcomes themselves: Outcome Measures explains what is measured; adjudication explains how designated endpoint events are reviewed or classified.
Further guidance
Content
Describe which endpoints are adjudicated, the adjudication body or reviewers, relevant independence or blinding arrangements, decision procedures, and where fuller committee or charter information can be found when applicable.
Purpose
Show readers how endpoint classification decisions are made when adjudication is part of the trial.
Sources and evidence
Sources are shown with the role they play in this guide. Historical or style-sensitive claims are kept within the evidence boundary described above.
- SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials (opens in a new tab)BMJ / SPIRIT-CONSORT Group · Primary SPIRIT 2025 explanation and elaboration for trial protocols, including trial monitoring and data monitoring committee roles and reporting structure.